Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock

医学 感染性休克 败血症 重症监护医学 随机对照试验 重症监护室 相对风险 内科学 置信区间
作者
Mohd H. Abdul–Aziz,Naomi Hammond,Stephen J. Brett,Menino Osbert Cotta,Jan J. De Waele,Anthony Devaux,Gian Luca Di Tanna,Joel M. Dulhunty,Hatem Elkady,Lars Eriksson,Mohd Shahnaz Hasan,Ayesha Bibi Khan,Jeffrey Lipman,Xiaoqiu Liu,Giacomo Monti,John Myburgh,Emmanuel Novy,S Omar,Dorrilyn Rajbhandari,Claire Roger,Fredrik Sjövall,Irene Zaghi,Alberto Zangrillo,Anthony Delaney,Jason A. Roberts
出处
期刊:JAMA [American Medical Association]
卷期号:332 (8): 638-638 被引量:6
标识
DOI:10.1001/jama.2024.9803
摘要

Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock. Objective To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions. Data Sources The primary search was conducted with MEDLINE (via PubMed), CINAHL, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov from inception to May 2, 2024. Study Selection Randomized clinical trials comparing prolonged (continuous or extended) and intermittent infusions of β-lactam antibiotics in critically ill adults with sepsis or septic shock. Data Extraction and Synthesis Data extraction and risk of bias were assessed independently by 2 reviewers. Certainty of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. A bayesian framework was used as the primary analysis approach and a frequentist framework as the secondary approach. Main Outcomes and Measures The primary outcome was all-cause 90-day mortality. Secondary outcomes included intensive care unit (ICU) mortality and clinical cure. Results From 18 eligible randomized clinical trials that included 9108 critically ill adults with sepsis or septic shock (median age, 54 years; IQR, 48-57; 5961 men [65%]), 17 trials (9014 participants) contributed data to the primary outcome. The pooled estimated risk ratio for all-cause 90-day mortality for prolonged infusions of β-lactam antibiotics compared with intermittent infusions was 0.86 (95% credible interval, 0.72-0.98; I 2 = 21.5%; high certainty), with a 99.1% posterior probability that prolonged infusions were associated with lower 90-day mortality. Prolonged infusion of β-lactam antibiotics was associated with a reduced risk of intensive care unit mortality (risk ratio, 0.84; 95% credible interval, 0.70-0.97; high certainty) and an increase in clinical cure (risk ratio, 1.16; 95% credible interval, 1.07-1.31; moderate certainty). Conclusions and Relevance Among adults in the intensive care unit who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions. The current evidence presents a high degree of certainty for clinicians to consider prolonged infusions as a standard of care in the management of sepsis and septic shock. Trial Registration PROSPERO Identifier: CRD42023399434
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
加湿器应助科研通管家采纳,获得40
刚刚
刚刚
科研通AI2S应助科研通管家采纳,获得10
刚刚
大个应助科研通管家采纳,获得10
刚刚
1秒前
lm发布了新的文献求助10
1秒前
2秒前
迟迟完成签到,获得积分10
2秒前
4秒前
sx完成签到 ,获得积分10
5秒前
5秒前
you发布了新的文献求助30
6秒前
清888应助chai采纳,获得10
7秒前
Loong312完成签到,获得积分10
8秒前
迟迟发布了新的文献求助10
9秒前
10秒前
wsdw56完成签到,获得积分10
10秒前
SEAMUS完成签到,获得积分20
12秒前
JamesPei应助文艺花生采纳,获得30
12秒前
14秒前
明亮淇完成签到 ,获得积分10
15秒前
滴滴嘟完成签到,获得积分10
15秒前
啦啦小王~完成签到,获得积分10
16秒前
小迪发布了新的文献求助10
17秒前
我是老大应助coco采纳,获得30
18秒前
19秒前
19秒前
难过的钥匙完成签到 ,获得积分10
22秒前
25秒前
机灵柚子完成签到,获得积分0
27秒前
27秒前
阳光沛凝完成签到,获得积分10
28秒前
guoyunlong完成签到,获得积分10
29秒前
GG发布了新的文献求助10
29秒前
coco发布了新的文献求助30
32秒前
眼睛大的尔竹完成签到 ,获得积分10
34秒前
小迪完成签到,获得积分20
34秒前
Hysen_L完成签到,获得积分10
35秒前
36秒前
GG完成签到,获得积分10
37秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Genera Insectorum: Mantodea, Fam. Mantidæ, Subfam. Hymenopodinæ (Classic Reprint) 800
Ethnicities: Media, Health, and Coping 700
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3086063
求助须知:如何正确求助?哪些是违规求助? 2738975
关于积分的说明 7552581
捐赠科研通 2388790
什么是DOI,文献DOI怎么找? 1266693
科研通“疑难数据库(出版商)”最低求助积分说明 613547
版权声明 598591