化学
组织谷氨酰胺转胺酶
二肽
硫
生物化学
酶抑制剂
细胞外
酶
京尼平
水溶性
立体化学
肽
有机化学
盐（化学）
壳聚糖
作者
Martin Griffin,Alexandre Mongeot,Russell Collighan,Robert E. Saint,Richard A. Jones,I. G. C. Coutts,Daniel L. Rathbone
标识
DOI：10.1016/j.bmcl.2008.09.006
摘要
Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-l-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase.
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