Poly(ε‐caprolactone) Biomaterial Sterilized by E‐Beam Irradiation

辐照 肿胀 的 生物相容性 电子顺磁共振 动态力学分析 己内酯 材料科学 生物材料 聚合物 化学 高分子化学 化学工程 复合材料 聚合 有机化学 纳米技术 核磁共振 核物理学 工程类 物理
作者
Katarzyna Filipczak,Magdalena Woźniak,Piotr Ulański,László Oláh,G. Przybytniak,Radosław Olkowski,M. Lewandowska‐Szumieł,Janusz M. Rosiak
出处
期刊:Macromolecular Bioscience [Wiley]
卷期号:6 (4): 261-273 被引量:49
标识
DOI:10.1002/mabi.200500215
摘要

Abstract Summary: The effects of ionizing radiation (electron beam) on poly( ε ‐caprolactone) (PCL) were studied by analyzing changes in viscosity‐average and weight‐average molecular weight and radius of gyration, and by performing sol‐gel analysis and swelling tests. Samples were irradiated under various conditions: solid and molten PCL in the presence or absence of air. The overall efficiency of crosslinking is higher for samples irradiated in the molten state than in the solid state, and is reduced in the presence of oxygen. Based on three kinds of experiments (molecular weight dependence on the dose in the pre‐gelation region, sol‐gel analysis, and swelling study), radiation‐chemical yields of intermolecular crosslinking and scission were determined and are discussed in terms of the mechanism of radiation‐induced reactions in PCL. Properties of the gels formed by high‐dose irradiation and mechanical properties of irradiated PCL were analyzed. Irradiation causes an increase in the compression modulus of PCL. This process occurs at the pre‐gelation stage and continues in the gel‐containing system. We have demonstrated, for the first time, that irradiation of solid PCL is accompanied by a pronounced post‐effect, which manifests itself by changes in the average molecular weight. EPR data indicate that this effect, at least in part, is caused by the presence of long‐lived radicals trapped in the crystalline regions. Irradiation with the sterilizing dose does not cause a statistically significant change in the biocompatibility of PCL after subsequent storage for 79 d, as determined by preliminary osteoblast vitality tests. Changes in the molecular weight upon irradiation and subsequent storage of poly( ε ‐caprolactone). image Changes in the molecular weight upon irradiation and subsequent storage of poly( ε ‐caprolactone).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
过时的毛豆完成签到,获得积分10
刚刚
Eazin完成签到,获得积分10
1秒前
11完成签到,获得积分10
3秒前
酷酷小子发布了新的文献求助10
4秒前
刘慧鑫发布了新的文献求助20
7秒前
研友_VZG7GZ应助jjj采纳,获得10
7秒前
8秒前
9秒前
WD发布了新的文献求助10
13秒前
sprite发布了新的文献求助20
14秒前
15秒前
16秒前
HHHAN发布了新的文献求助10
16秒前
地表飞猪应助zychaos采纳,获得10
18秒前
大模型应助微笑的语芙采纳,获得10
20秒前
田様应助zzzzzz采纳,获得10
20秒前
21秒前
王晓静完成签到 ,获得积分10
22秒前
23秒前
顾矜应助时安采纳,获得10
23秒前
nv完成签到,获得积分10
24秒前
烟花应助回鱼采纳,获得10
24秒前
狡猾的菠萝完成签到 ,获得积分10
24秒前
27秒前
斯文败类应助炫哥IRIS采纳,获得10
27秒前
杜杨帆发布了新的文献求助10
28秒前
冷艳的友瑶完成签到,获得积分10
29秒前
29秒前
脑洞疼应助要吃虾饺吗采纳,获得30
30秒前
30秒前
li发布了新的文献求助30
32秒前
Owen应助科研通管家采纳,获得10
33秒前
科研通AI5应助科研通管家采纳,获得10
33秒前
不懈奋进应助科研通管家采纳,获得30
33秒前
SYLH应助科研通管家采纳,获得10
33秒前
SYLH应助科研通管家采纳,获得10
33秒前
SYLH应助科研通管家采纳,获得10
33秒前
慕青应助科研通管家采纳,获得10
34秒前
34秒前
FashionBoy应助科研通管家采纳,获得10
34秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3979719
求助须知:如何正确求助?哪些是违规求助? 3523760
关于积分的说明 11218505
捐赠科研通 3261224
什么是DOI,文献DOI怎么找? 1800507
邀请新用户注册赠送积分活动 879117
科研通“疑难数据库(出版商)”最低求助积分说明 807182