变构调节
DNA
计算机科学
DNA折纸
变构酶
纳米技术
化学
材料科学
受体
生物化学
作者
Cheng Zhang,Xueying Ma,Xuedong Zheng,Yonggang Ke,Kuiting Chen,Dongsheng Liu,Zuhong Lu,Jing Yang,Hao Yan
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-02-02
卷期号:8 (5)
被引量:40
标识
DOI:10.1126/sciadv.abl4589
摘要
Structure-based molecular regulations have been widely adopted to modulate protein networks in cells and recently developed to control allosteric DNA operations in vitro. However, current examples of programmable allosteric signal transmission through integrated DNA networks are stringently constrained by specific design requirements. Developing a new, more general, and programmable scheme for establishing allosteric DNA networks remains challenging. Here, we developed a general strategy for programmable allosteric DNA regulations that can be finely tuned by varying the dimensions, positions, and number of conformational signals. By programming the allosteric signals, we realized fan-out/fan-in DNA gates and multiple-layer DNA cascading networks, as well as expanding the approach to long-range allosteric signal transmission through tunable DNA origami nanomachines ~100 nm in size. This strategy will enable programmable and complex allosteric DNA networks and nanodevices for nanoengineering, chemical, and biomedical applications displaying sense-compute-actuate molecular functionalities.
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