细胞外小泡
肝细胞
细胞外
肝纤维化
纤维化
化学
生物
细胞生物学
内科学
生物化学
医学
体外
作者
Xianzhi Liu,Siwei Tan,Huiling Liu,Jie Jiang,Xing Wang,Leijia Li,Bin Wu
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2022-07-18
卷期号:77 (4): 1181-1197
被引量:88
摘要
ARRB1 up-regulates the release of hepatocyte-derived MASP1-enriched small EVs by regulating the autophagic-lysosomal/multivesicular body pathway and Rab27A. Hepatocyte-derived MASP1 activates HSCs to promote liver fibrogenesis through p38 MAPK/ATF2 signaling. Thus, MASP1 is a pivotal therapeutic target in liver fibrosis.
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