化学
异喹啉
串联
碳阳离子
芳基
级联反应
药物化学
组合化学
有机化学
催化作用
复合材料
材料科学
烷基
作者
Khalil Alatat,Alireza Abbasi Kejani,Ali M. Nikbakht,Hamid Reza Bijanzadeh,Saeed Balalaie
摘要
A tandem reaction of 2-alkynylbenzaldoximes with propargylic alcohols has been developed for the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenones. Employing 2-alkynylbenzaldoximes as a precursor in the presence of Br2 generates 4-bromo-isoquinoline-N-oxides. Subsequently, dehydroxylation of propargylic alcohols gives carbocation intermediates, which are trapped using the N-oxides, affording aryl-substituted α-enones.
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