NMR Relaxometric Properties of SPION-Loaded Solid Lipid Nanoparticles

纳米颗粒 超顺磁性 固体脂质纳米粒 材料科学 放松(心理学) 扩散 质子 化学 核磁共振 分析化学(期刊) 纳米技术 色谱法 磁化 热力学 磁场 量子力学 社会心理学 物理 心理学
作者
Lucia Calucci,Agostina Grillone,Eugenio Redolfi Riva,Virgilio Mattoli,Gianni Ciofani,Claudia Forte
出处
期刊:Journal of Physical Chemistry C [American Chemical Society]
卷期号:121 (1): 823-829 被引量:10
标识
DOI:10.1021/acs.jpcc.6b09562
摘要

Longitudinal and transverse relaxivities of solid lipid nanoparticles loaded with superparamagnetic iron oxide nanoparticles (SPION-SLNs) were thoroughly investigated with the aim of understanding the main parameters regulating the potential negative contrast properties of these systems. In particular, the longitudinal relaxivity (r1) of water protons in the 10 kHz to 35 MHz frequency range was determined by 1H fast field-cycling NMR, while transverse relaxivity (r2) was measured at 21 MHz. The reproducibility and stability of SPION-SLNs was also tested on samples arising from independent preparations and at different times after preparation. Water diffusion in proximity of superparamagnetic nanoparticles was found to be the mechanism of proton nuclear relaxation enhancement and characteristic parameters were quantitatively determined by fitting the experimental data acquired on different samples as a function of concentration and temperature. Although a variation ascribable to the formation of clusters with a different number of SPIONs inhomogeneously embedded in the lipid matrix was observed among different preparations, the relaxivity properties of the investigated SPION-SLNs were found to be better than those of SPION-based contrast agents commonly considered as standard in the literature, and remained stable for at least 2 months.
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