Drug-eluting balloon: Very short-term exposure and overlapping

再狭窄 医学 气球 冠状动脉 紫杉醇 血管成形术 支架 管腔(解剖学) 狭窄 扬抑 药物洗脱支架 心脏病学 动脉 放射科 核医学 内科学 外科 化疗
作者
Bodo Cremers,Ulrich Speck,Nicola Stolzenburg,Dirk Mahnkopf,Michael Kühler,Michael Böhm,Bruno Scheller
出处
期刊:Thrombosis and Haemostasis [Georg Thieme Verlag KG]
卷期号:101 (01): 201-206 被引量:103
标识
DOI:10.1160/th08-06-0387
摘要

Summary Paclitaxel balloon coating has shown promising effects in inhibiting restenosis in initial clinical trials. The aim of the present study was to evaluate the influence of two critical features of drug-eluting balloon (DEB) application – inflation time and increased dose due to overlapping balloons. Fifty-six stainless steel stents were implanted in the left anterior descending and circumflex coronary arteries of 28 domestic pigs using a 1.2:1.0 overstretch ratio. Stents were mounted on conventional un-coated and paclitaxel-coated angioplasty balloon catheters. The animals were randomized to five different treatments with a range of short (10 seconds [s] inflation using 1 DEB) to extended (2x60 s inflation using 2 DEB) intima contact time. After 28 days, quantitative angiography and histomorphometry of the stented arteries was performed on a total of 23 pigs. Paclitaxel balloon coating led to a marked reduction of parameters characterizing in-stent stenosis: Late lumen loss was 1.37 ± 0.49 mm for uncoated balloons, 0.23 ± 0.42 mm for one coated balloon 60 s inflation time, 0.37 ± 0.28 mm for 10 s inflation time and 0.30 ± 0.19 mm for the vessel segment treated by two coated balloons with 60 s inflation each. Neointimal areas were 4.26 ± 1.18, 1.68 ± 0.23, 1.83 ± 0.40 and 1.67 ± 0.46 mm², respectively (p=0.001 versus control, p>0.05 between paclitaxel-treated groups). Despite the marked reduction of neointimal proliferation, endothelialization of stent struts was present in all samples. DEB were found to effectively reduce neointimal proliferation regardless of inflation time and dose within the tested range. No adverse reactions were seen as dose was increased to more than three times the clinically tested dose.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
难过友易完成签到,获得积分20
1秒前
1秒前
insissst完成签到,获得积分10
1秒前
FashionBoy应助天天开心采纳,获得30
2秒前
2秒前
3秒前
CodeCraft应助hua采纳,获得10
3秒前
3秒前
powfu发布了新的文献求助10
3秒前
兰闹儿完成签到,获得积分10
4秒前
4秒前
4秒前
5秒前
12334发布了新的文献求助10
5秒前
123应助呆会儿采纳,获得10
5秒前
畅快的觅风完成签到,获得积分20
5秒前
mrhsdy完成签到,获得积分10
6秒前
zzzzz发布了新的文献求助10
6秒前
lyt发布了新的文献求助20
7秒前
兰闹儿发布了新的文献求助30
7秒前
7秒前
8秒前
美好的从阳完成签到,获得积分10
8秒前
9秒前
甄水瑶发布了新的文献求助30
10秒前
屿落完成签到,获得积分10
11秒前
yzz完成签到,获得积分10
11秒前
傲娇凉面发布了新的文献求助10
11秒前
直率的山菡完成签到,获得积分20
12秒前
情怀应助军军问问张采纳,获得10
13秒前
屿落发布了新的文献求助10
14秒前
14秒前
14秒前
Cool完成签到,获得积分10
15秒前
June-ho发布了新的文献求助10
15秒前
小蘑菇应助阔达的海蓝采纳,获得10
15秒前
lee发布了新的文献求助10
15秒前
爆米花应助四十四次日落采纳,获得10
16秒前
从容的幻柏完成签到,获得积分10
16秒前
SHIDO完成签到,获得积分20
17秒前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3051601
求助须知:如何正确求助?哪些是违规求助? 2708914
关于积分的说明 7414939
捐赠科研通 2353282
什么是DOI,文献DOI怎么找? 1245459
科研通“疑难数据库(出版商)”最低求助积分说明 605681
版权声明 595846