化学
环丙烷
取代基
部分
吲哚
立体化学
细胞毒性
结构-活动关系
磺酰
化学合成
微管
体外
生物化学
戒指(化学)
有机化学
细胞生物学
生物
烷基
作者
Jun Yang,Shanshan Zhou,Liyan Ji,Chao Zhang,Siwang Yu,Zhongjun Li,Xiangbao Meng
标识
DOI:10.1016/j.bmcl.2014.09.016
摘要
A series of 1-sulfonyl indolines was synthesized and evaluated for antiproliferative activity. The most potent compounds 9a and 9e showed significant cytotoxicity (IC50 in the range of 0.055–0.105 and 0.039–0.112 μM, respectively) against four human cancer cell lines HCT116, PC3, HepG2 and SK-OV-3. The structure–activity relationship of this series of sulfonamides, including the influence of azaheterocycle rings, substituent at the different positions of indoline, and the cyclopropane moiety, was described.
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