生物
平衡
细胞因子
细胞生物学
先天性淋巴细胞
免疫学
受体
信号转导
细胞因子受体
功能(生物学)
免疫系统
免疫
遗传学
作者
Averil Ma,Rima Koka,Patrick R. Burkett
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2006-01-16
卷期号:24 (1): 657-679
被引量:808
标识
DOI:10.1146/annurev.immunol.24.021605.090727
摘要
IL-2, IL-15, and IL-7 are cytokines that are critical for regulating lymphoid homeostasis. These cytokines stimulate similar responses from lymphocytes in vitro, but play markedly divergent roles in lymphoid biology in vivo. Their distinct physiological functions can be ascribed to distinct signaling pathways initiated by proprietary cytokine receptor chains, differential expression patterns of the cytokines or their receptor chains, and/or signals occurring in distinct physiological contexts. Recently, the discovery of a novel mechanism of cytokine signaling, trans-presentation, has provided further insights into the different ways these cytokines function. Trans-presentation also raises several novel cell biological and cellular implications concerning how cytokines support lymphoid homeostasis.
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