亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Liver–Microbiome Axis in Health and Disease

微生物群 肝性脑病 原发性硬化性胆管炎 肝硬化 免疫学 酒精性肝炎 疾病 脂肪肝 酒精性肝病 肝病 医学 非酒精性脂肪肝 肠道菌群 失调 胃肠病学 生物 内科学 生物信息学
作者
Timon E. Adolph,Christoph Grander,Alexander R. Moschen,Herbert Tilg
出处
期刊:Trends in Immunology [Elsevier BV]
卷期号:39 (9): 712-723 被引量:141
标识
DOI:10.1016/j.it.2018.05.002
摘要

An intestinal microbiome signature is emerging in various liver diseases independent of disease stage. Microbiota profiles may differ between various liver disease etiologies. Microbiota and microbiota-derived factors have a key role in liver cirrhosis and associated pathologies. Advanced liver disease is characterized by a circulating microbiome. Some commensals prevent liver disease in preclinical studies. The intestinal and hepatobiliary tract exhibits host-specific commensal colonization. The resident microbiota has emerged as a key player in intestinal and hepatic diseases. Alcoholic and nonalcoholic fatty liver diseases (ALD/NAFLD), primary sclerosing cholangitis (PSC), liver cirrhosis, and some of their clinical complications, such as hepatic encephalopathy (HE), have been linked to a microbial signature, as also observed for severe liver inflammation in alcoholic hepatitis. In turn, the liver impacts, and communicates with, the microbiota through hepatic mediators, such as bile acids or inflammatory signals. Therefore, a liver–microbiome bidirectional crosstalk appears to be critical in health and various liver diseases and could be therapeutically targeted, such as by fecal microbiota transplantation. The intestinal and hepatobiliary tract exhibits host-specific commensal colonization. The resident microbiota has emerged as a key player in intestinal and hepatic diseases. Alcoholic and nonalcoholic fatty liver diseases (ALD/NAFLD), primary sclerosing cholangitis (PSC), liver cirrhosis, and some of their clinical complications, such as hepatic encephalopathy (HE), have been linked to a microbial signature, as also observed for severe liver inflammation in alcoholic hepatitis. In turn, the liver impacts, and communicates with, the microbiota through hepatic mediators, such as bile acids or inflammatory signals. Therefore, a liver–microbiome bidirectional crosstalk appears to be critical in health and various liver diseases and could be therapeutically targeted, such as by fecal microbiota transplantation. liver-derived cholesterol derivates that control digestion, and modulate the microbiota and metabolism. a term for lipid accumulation in hepatocytes. a term for late-stage liver disease (irrespective of the underlying pathology) that is characterized by scarring and fibrosis. all the genetic material present in an environmental sample (i.e., host cells plus microorganisms). the entire microbial flora or collection of microbial genes from bacteria, viruses, or fungi in a given environment (e.g., intestine). usually benign endogenous microbes that might turn pathogenic if ecosystem changes. a complication of liver cirrhosis that is characterized by increased pressure in the portal circulation leading to esophageal varices, spleen enlargement, and other signs of advanced liver disease. a chronic disease with characteristic bile duct strictures that damage the liver, eventually culminating in liver cirrhosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
年年有余完成签到,获得积分10
2秒前
胖小羊完成签到 ,获得积分10
52秒前
1分钟前
领导范儿应助科研通管家采纳,获得10
1分钟前
1分钟前
juan完成签到 ,获得积分10
2分钟前
学术小垃圾完成签到,获得积分10
3分钟前
叁月二完成签到 ,获得积分10
3分钟前
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
大模型应助科研通管家采纳,获得10
3分钟前
xingsixs完成签到 ,获得积分10
4分钟前
AprilLeung完成签到 ,获得积分10
5分钟前
5分钟前
深情安青应助科研通管家采纳,获得10
5分钟前
迷茫的一代完成签到,获得积分10
6分钟前
魔笛的云宝完成签到 ,获得积分10
6分钟前
www完成签到,获得积分10
7分钟前
7分钟前
NexusExplorer应助科研通管家采纳,获得10
7分钟前
Akitten发布了新的文献求助10
8分钟前
啥时候吃火锅完成签到 ,获得积分0
9分钟前
上官若男应助科研通管家采纳,获得30
9分钟前
斯文败类应助科研通管家采纳,获得10
9分钟前
李爱国应助科研通管家采纳,获得10
9分钟前
科研通AI2S应助科研通管家采纳,获得10
9分钟前
赘婿应助科研通管家采纳,获得10
9分钟前
田様应助精明晓刚采纳,获得10
10分钟前
10分钟前
精明晓刚发布了新的文献求助10
10分钟前
科研通AI2S应助科研通管家采纳,获得10
11分钟前
coolplex完成签到 ,获得积分10
12分钟前
wwe完成签到,获得积分10
12分钟前
貔貅完成签到 ,获得积分10
13分钟前
yindi1991完成签到 ,获得积分10
15分钟前
hgl完成签到,获得积分10
15分钟前
15分钟前
科研通AI2S应助科研通管家采纳,获得10
15分钟前
15分钟前
华仔应助精明晓刚采纳,获得10
16分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990423
求助须知:如何正确求助?哪些是违规求助? 3532158
关于积分的说明 11256513
捐赠科研通 3271046
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234