溃疡性结肠炎
医学
胃肠病学
腹泻
内科学
发病机制
结肠炎
酶
疾病
生物化学
化学
作者
D Rachmilewitz,Fanny Karmeli,P. Sharon
出处
期刊:PubMed
日期:1984-08-01
卷期号:20 (8): 681-4
被引量:35
摘要
Na-K-ATPase has an important role in intestinal sodium and fluid absorption. We tested the colonic activity of this enzyme in patients with active ulcerative colitis to elucidate its role in the pathogenesis of the diarrhea associated with this disease. Colonic Na-K-ATPase activity in 13 patients with active ulcerative colitis prior to therapy was one-fourth of its activity in 14 normal subjects: 0.68 +/- 0.13 (SE) and 2.60 +/- 0.45 mumol/h . mg protein, respectively. In six patients with active ulcerative colitis on steroid therapy, the enzyme activity was similar to that observed in normal subjects. These results indicate an inhibition of colonic Na-K-ATPase activity in active ulcerative colitis, which may contribute to intestinal fluid accumulation and thus to the diarrhea in this disease.
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