纳米纤维
堆积
材料科学
分子间力
芳香性
氨基酸
芳香族氨基酸
两亲性
生物物理学
淀粉样蛋白(真菌学)
纳米技术
组合化学
有机化学
分子
生物
化学
生物化学
聚合物
复合材料
植物
共聚物
作者
Bibin G. Anand,Kailash Prasad Prajapati,Masihuzzaman Ansari,Deepak Yadav,Mayur Temgire,Karunakar Kar
标识
DOI:10.1021/acsami.1c04161
摘要
Considering the relevance of accumulation and self-assembly of metabolites and aftermath of biological consequences, it is important to know whether they undergo coassembly and what properties the resultant hybrid higher-order structures would exhibit. This work reveals the inherent tendency of aromatic amino acids to undergo a spontaneous coassembly process under physiologically mimicked conditions, which yields neurotoxic hybrid nanofibers. Resultant hybrid nanostructures resembled the β-structured conformers stabilized by H-bonds and π-π stacking interactions, which were highly toxic to human neuroblastoma cells. The hybrid nanofibers also showed strong cross-seeding potential that triggered in vitro aggregation of diverse globular proteins and brain extract components, converting the native structures into cross-β-rich amyloid aggregates. The heterogenic nature of the hybrid nanofibers seems crucial for their higher toxicity and faster cross-seeding potential as compared to the homogeneous amino acid nanofibers. Our findings reveal the importance of aromaticity-driven optimized intermolecular arrangements for the coassembly of aromatic amino acids, and the results may provide important clues to the fundamental understanding of metabolite accumulation-related complications.
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