Liraglutide changes body composition and lowers added sugar intake in overweight persons with insulin pump‐treated type 1 diabetes

利拉鲁肽 超重 医学 安慰剂 内科学 内分泌学 胰岛素 肥胖 1型糖尿病 2型糖尿病 糖尿病 瘦体质量 置信区间 减肥 体重 替代医学 病理
作者
Signe Schmidt,Christian S. Frandsen,Thomas F. Dejgaard,Dorte Vistisen,Þórhallur I. Halldórsson,Sjúrður F. Olsen,Jens‐Erik Beck Jensen,Sten Madsbad,Henrik U. Andersen,Kirsten Nørgaard
出处
期刊:Diabetes, Obesity and Metabolism [Wiley]
卷期号:24 (2): 212-220 被引量:12
标识
DOI:10.1111/dom.14567
摘要

Abstract Aims To present secondary outcome analyses of liraglutide treatment in overweight adults with insulin pump‐treated type 1 diabetes (T1D), focusing on changes in body composition and dimensions, and to evaluate changes in food intake to identify potential dietary drivers of liraglutide‐associated weight loss. Materials and methods A 26‐week randomized placebo‐controlled study was conducted to investigate the efficacy and safety of liraglutide 1.8 mg daily in 44 overweight adults with insulin pump‐treated T1D and glucose levels above target, and demonstrated significant glycated haemoglobin (HbA1c)‐ and body weight‐reducing effects. For secondary outcome analysis, dual X‐ray absorptiometry scans were completed at Weeks 0 and 26, and questionnaire‐based food frequency recordings were obtained at Weeks 0, 13 and 26 to characterize liraglutide‐induced changes in body composition and food intake. Results Total fat and lean body mass decreased in liraglutide‐treated participants (fat mass −4.6 kg [95% confidence interval {CI} −5.7; −3.5], P < 0.001; lean mass −2.5 kg [95% CI −3.2;‐1.7], P < 0.001), but remained stable in placebo‐treated participants (fat mass −0.3 kg [95% CI −1.3;0.8], P = 0.604; lean mass 0.0 kg [95% CI −0.7;0.7]; P = 0.965 [between‐group P values <0.001]). Participants reduced their energy intake numerically more in the liraglutide arm (−1.1 MJ [95% CI −2.0;‐0.02], P = 0.02) than in the placebo arm (−0.9 MJ [95% CI −2.0;0.1], P = 0.22), but the between‐group difference was statistically insignificant ( P = 0.42). However, energy derived from added sugars decreased by 27% in the liraglutide arm compared with an increase of 14% in the placebo arm ( P = 0.004). Conclusions Liraglutide lowered fat and lean body mass compared with placebo. Further, liraglutide reduced intake of added sugars. However, no significant difference in total daily energy intake was detected between liraglutide‐ and placebo‐treated participants.
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