Recent Advances in C(sp3)—H Phosphorylation Based on Secondary Phosphine Oxides and Phosphite Esters

Organophosphorus compounds bearing C(sp 3 )-P bonds have been widely used in organic synthesis, bioorganic and medical chemistry, agrochemicals, flame retardants and extractants.In recent years, the direct phosphorylation of C-H bonds has received much attention because this strategy represents more straightforward, efficient and atom-economic construction of C-P bonds.The recent advances in C(sp 3 )-H phosphorylation using secondary phosphine oxides and phosphite esters as phosphorus sources since 2009 are reviewed, and the corresponding reactions are categorized in five types according to the structure of C(sp 3 )-H bonds.