亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Clinical Significance of Horizontal and Vertical Margin of En Bloc Resection for Nonmuscle Invasive Bladder Cancer

医学 边距(机器学习) 尿路上皮癌 临床意义 外科 膀胱癌 癌症 切除缘 切除术 病理 内科学 计算机科学 机器学习
作者
Takafumi Yanagisawa,Jun Miki,Keigo Sakanaka,Wataru Fukuokaya,Kosuke Iwatani,Shun Sato,Koki Obayashi,Shinichi Hirooka,Takahiro Kimura,Hiroyuki Takahashi,Shin Egawa
出处
期刊:The Journal of Urology [Lippincott Williams & Wilkins]
卷期号:206 (2): 252-259 被引量:16
标识
DOI:10.1097/ju.0000000000001735
摘要

No AccessJournal of UrologyAdult Urology1 Aug 2021Clinical Significance of Horizontal and Vertical Margin of En Bloc Resection for Nonmuscle Invasive Bladder Cancer Takafumi Yanagisawa, Jun Miki, Keigo Sakanaka, Wataru Fukuokaya, Kosuke Iwatani, Shun Sato, Koki Obayashi, Shinichi Hirooka, Takahiro Kimura, Hiroyuki Takahashi, and Shin Egawa Takafumi YanagisawaTakafumi Yanagisawa *Correspondence: Department of Urology, The Jikei University Kashiwa Hospital, 163-1 Kashiwashita, Kashiwa, Chiba , 277-8567Japan telephone: +81-4-7164-1111; FAX: +81-4-7166-9374; E-mail Address: [email protected] http://orcid.org/0000-0002-7410-0712 Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Jun MikiJun Miki Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Keigo SakanakaKeigo Sakanaka Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Wataru FukuokayaWataru Fukuokaya Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Kosuke IwataniKosuke Iwatani Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Shun SatoShun Sato Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Koki ObayashiKoki Obayashi Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Shinichi HirookaShinichi Hirooka Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Takahiro KimuraTakahiro Kimura Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , Hiroyuki TakahashiHiroyuki Takahashi Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author , and Shin EgawaShin Egawa Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001735AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The primary advantage of en bloc resection of bladder tumors is to provide better diagnostic accuracy. However, the clinical significance of horizontal and vertical margin has not been demonstrated. We evaluated the clinical importance of surgical margins in patients who underwent en bloc resection of bladder tumors. Materials and Methods: We retrospectively analyzed the records of 140 consecutive patients who underwent en bloc resection of bladder tumors for nonmuscle invasive bladder cancer. We analyzed perioperative and oncological outcome, and compared patient demographics and recurrence-free survival for horizontal findings. The relationship between surgical margin and second transurethral resection outcome in pT1 bladder cancer was also analyzed. Results: Mean tumor diameter was 17.2±9.8 mm. Pathological stages were 93 cases in pTa and 47 cases in pT1. Diagnostic rates for the horizontal and vertical margins were 63% and 99%, respectively. The rates of sessile, carcinoma in situ, high grade, and pT1 tumors were significantly higher in the horizontal margin positive group (41) than in the negative group (47). There was no significant difference in 2-year recurrence-free survival based on horizontal margin findings (negative: 72.4%, positive: 75.4%, p=0.87). A second transurethral resection was performed in 31 of the 47 pT1 patients; pT1 residue was seen only in vertical margin positive cases, and 5 pTa/pTis residues at the transurethral resection scar were seen in 15 horizontal margin positive patients. Conclusions: Horizontal margin positive findings were not associated with recurrence-free survival, but careful assessment is warranted regarding residue at the original site. A second transurethral resection should be considered in patients with horizontal and vertical margin positive pT1 bladder cancer. References 1. : European Association of Urology guidelines on non-muscle-invasive bladder cancer (TaT1 and carcinoma in situ)—2019 update. Eur Urol 2019; 76: 639. Google Scholar 2. : Current concept of transurethral resection of bladder cancer: from re-transurethral resection of bladder cancer to en-bloc resection. Curr Opin Urol 2018; 28: 591. Google Scholar 3. : A new technique for transurethral resection of superficial bladder tumor in 1 piece. J Urol 2000; 163: 878. Link, Google Scholar 4. : En bloc transurethral resection with 2-micron continuous-wave laser for primary non-muscle-invasive bladder cancer: a randomized controlled trial. World J Urol 2015; 33: 989. Google Scholar 5. : Comparison of the safety and efficacy of conventional monopolar and 2-micron laser transurethral resection in the management of multiple nonmuscle-invasive bladder cancer. J Int Med Res 2013; 41: 984. Google Scholar 6. : Current evidence of transurethral en-bloc resection of nonmuscle invasive bladder cancer: update 2016. Eur Urol Focus 2017; 3: 567. Google Scholar 7. : The safety and efficacy of front-firing green-light laser endoscopic en bloc photoselective vapo-enucleation of non-muscle-invasive bladder cancer. Ther Clin Risk Manag 2017; 13: 983. Google Scholar 8. : A pilot study to assess the safety and usefulness of combined transurethral endoscopic mucosal resection and en-bloc resection for non-muscle invasive bladder cancer. BMC Urol 2019; 19: 56. Google Scholar 9. : En bloc re-resection of high-risk NMIBC after en bloc resection: results of a multicenter observational study. World J Urol 2020; 38: 703. Google Scholar 10. : A retrospective comparison of thulium laser en bloc resection of bladder tumor and plasmakinetic transurethral resection of bladder tumor in primary non-muscle invasive bladder cancer. Lasers Med Sci 2019; 34: 85. Google Scholar 11. : En bloc resection improves the identification of muscularis mucosae in non-muscle invasive bladder cancer. World J Urol 2019; 37: 2677. Google Scholar 12. : Transurethral en bloc resection with bipolar button electrode for non-muscle invasive bladder cancer. Int Urol Nephrol 2018; 50: 619. Google Scholar 13. : A novel transurethral resection technique for superficial bladder tumor: retrograde en bloc resection. World J Surg Oncol 2017; 15: 125. Google Scholar 14. : Transurethral resection in one piece (TURBO) is an accurate tool for pathological staging of bladder tumor. Int J Urol 2010; 17: 708. Google Scholar 15. : An international collaborative consensus statement on en bloc resection of bladder tumour incorporating two systematic reviews, a two-round Delphi survey, and a consensus meeting. Eur Urol 2020; 78: 546. Google Scholar 16. : Gastric cancer, version 3.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2016; 14: 1286. Google Scholar 17. : NCCN guidelines insights: colon cancer, version 2.2018. J Natl Compr Canc Netw 2018; 16: 359. Google Scholar 18. : Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: a comparison study of HybridKnife-assisted versus conventional dissection technique. J Cancer Res Ther 2018; 14: 1606. Google Scholar 19. : “En bloc” resection of nonmuscle invasive bladder cancer: a prospective single-center study. Urology 2016; 90: 126. Google Scholar 20. : En bloc resection of urothelium carcinoma of the bladder (EBRUC): a European multicenter study to compare safety, efficacy, and outcome of laser and electrical en bloc transurethral resection of bladder tumor. World J Urol 2015; 33: 1937. Google Scholar 21. : Bipolar plasma kinetic enucleation of non-muscle-invasive bladder cancer: initial experience with a novel technique. Arab J Urol 2017; 15: 355. Google Scholar 22. : Bipolar en bloc tumor resection versus standard monopolar TURBT—which is the best way to go in non-invasive bladder cancer?Rom J Morphol Embryol 2018; 59: 773. Google Scholar 23. : Safety and efficacy of en bloc transurethral resection with 1.9 μm Vela laser for treatment of non-muscle-invasive bladder cancer. Urology 2018; 113: 246. Google Scholar 24. : Comparing the safety and efficiency of conventional monopolar, plasmakinetic, and holmium laser transurethral resection of primary non-muscle invasive bladder cancer. J Endourol 2010; 24: 69. Google Scholar 25. : Is en-bloc transurethral resection of bladder tumor for non-muscle invasive bladder carcinoma better than conventional technique in terms of recurrence and progression?: a prospective study. Indian J Urol 2014; 30: 144. Google Scholar Author Contribution: TY contributed to protocol/project development, data collection and management, data analysis, and manuscript writing/editing. JM contributed to protocol/project development and manuscript editing. SS and SH contributed to pathological diagnosis. KS, WF, KI, and KO contributed to data collection. TK, HT, and SE contributed to manuscript editing. Ethics Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByYanagisawa T, Mori K, Motlagh R, Kawada T, Mostafaei H, Quhal F, Laukhtina E, Rajwa P, Aydh A, König F, Pallauf M, Pradere B, D'Andrea D, Compérat E, Miki J, Kimura T, Egawa S and Shariat S (2022) En Bloc Resection for Bladder Tumors: An Updated Systematic Review and Meta-Analysis of Its Differential Effect on Safety, Recurrence and HistopathologyJournal of Urology, VOL. 207, NO. 4, (754-768), Online publication date: 1-Apr-2022. Volume 206Issue 2August 2021Page: 252-259 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.Keywordsmargins of excisionurinary bladder neoplasmsAcknowledgmentsEnglish-language editorial support was provided by Seaman Medical, Inc., Bellingham, Washington, USA.MetricsAuthor Information Takafumi Yanagisawa Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan *Correspondence: Department of Urology, The Jikei University Kashiwa Hospital, 163-1 Kashiwashita, Kashiwa, Chiba , 277-8567Japan telephone: +81-4-7164-1111; FAX: +81-4-7166-9374; E-mail Address: [email protected] More articles by this author Jun Miki Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Keigo Sakanaka Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Wataru Fukuokaya Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Kosuke Iwatani Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Shun Sato Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Koki Obayashi Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Shinichi Hirooka Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Takahiro Kimura Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Hiroyuki Takahashi Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Shin Egawa Department of Urology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan More articles by this author Expand All Author Contribution: TY contributed to protocol/project development, data collection and management, data analysis, and manuscript writing/editing. JM contributed to protocol/project development and manuscript editing. SS and SH contributed to pathological diagnosis. KS, WF, KI, and KO contributed to data collection. TK, HT, and SE contributed to manuscript editing. Ethics Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. Advertisement Loading ...
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
深情安青应助科研通管家采纳,获得10
1秒前
迷茫的一代完成签到,获得积分10
55秒前
魔笛的云宝完成签到 ,获得积分10
1分钟前
www完成签到,获得积分10
1分钟前
1分钟前
NexusExplorer应助科研通管家采纳,获得10
2分钟前
Akitten发布了新的文献求助10
2分钟前
啥时候吃火锅完成签到 ,获得积分0
3分钟前
上官若男应助科研通管家采纳,获得30
4分钟前
斯文败类应助科研通管家采纳,获得10
4分钟前
李爱国应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
赘婿应助科研通管家采纳,获得10
4分钟前
田様应助精明晓刚采纳,获得10
4分钟前
4分钟前
精明晓刚发布了新的文献求助10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
coolplex完成签到 ,获得积分10
6分钟前
wwe完成签到,获得积分10
6分钟前
貔貅完成签到 ,获得积分10
7分钟前
yindi1991完成签到 ,获得积分10
9分钟前
hgl完成签到,获得积分10
9分钟前
9分钟前
科研通AI2S应助科研通管家采纳,获得10
10分钟前
10分钟前
华仔应助精明晓刚采纳,获得10
10分钟前
10分钟前
11分钟前
精明晓刚发布了新的文献求助10
11分钟前
糖伯虎完成签到 ,获得积分10
11分钟前
在水一方应助科研通管家采纳,获得10
12分钟前
光合作用完成签到,获得积分10
12分钟前
13分钟前
精明晓刚发布了新的文献求助10
13分钟前
精明晓刚完成签到,获得积分10
13分钟前
13分钟前
搜集达人应助kangkang采纳,获得10
13分钟前
英姑应助科研通管家采纳,获得10
14分钟前
kangkang完成签到,获得积分20
14分钟前
14分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990351
求助须知:如何正确求助?哪些是违规求助? 3532158
关于积分的说明 11256513
捐赠科研通 3271046
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234