机械敏感通道
机械转化
离子通道
神经科学
压电1
生物
伸展激活离子通道
遗传学
受体
出处
期刊:Annual Review of Neuroscience
[Annual Reviews]
日期:2020-07-08
卷期号:43 (1): 207-229
被引量:142
标识
DOI:10.1146/annurev-neuro-070918-050509
摘要
Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit their biological roles. How mechanosensitive channels work, especially in animals, has been extensively studied in the past decade. Here we review key findings in the functional and structural characterizations of these channels and highlight the structural features relevant to the mechanotransduction mechanism of each specific channel.
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