材料科学
乙二醇
化学工程
聚合物
PLGA公司
二氯甲烷
可生物降解聚合物
溶剂
乳状液
聚酯纤维
PEG比率
形态学(生物学)
纳米技术
高分子化学
复合材料
纳米颗粒
有机化学
化学
经济
工程类
生物
遗传学
财务
作者
Mubashir Hussain,Jun Xie,Ke Wang,Hua Wang,Zhengping Tan,Qianqian Liu,Zhen Geng,Khurram Shezad,Laila Noureen,Hao Jiang,Jiangping Xu,Lianbin Zhang,Jintao Zhu
标识
DOI:10.1021/acsami.9b14286
摘要
In this report, we present a facile approach to produce biodegradable polymeric microparticles with uniform sizes and controllable morphologies by blending hydrophobic poly(d, l-lactic-co-glycolide) (PLGA) and amphiphilic poly(d, l-lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) in a microfluidic chip. Microparticles with tentacular, hollow hemispherical, and Janus structures were obtained after complete evaporation of the organic solvent by manipulating the interfacial behavior of emulsion droplets and the phase separation behavior inside the droplets. The number and length of the tentacles on the surface of tentacular microparticles could be tailored by varying the initial concentration and blending ratios of the polymers. The organic solvent played an important role in controlling the morphologies of microparticles. For example, blending PLA16k-b-PEG5k with PLGA100k in dichloromethane resulted in tentacular microparticles, whereas hollow hemispherical microparticles were obtained in trichloromethane. Moreover, these microparticles with controllable shapes and surface textures have significant influence on the immune response of dendritic cells (DCs), showing a morphology-dependent enhancement of DC maturation.
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