荟萃分析
医学
炎症
生物标志物
虚弱综合征
C反应蛋白
压力源
肿瘤坏死因子α
内科学
白细胞介素6
老年学
虚弱指数
临床心理学
生物
生物化学
作者
Diego Marcos-Pérez,María Sánchez-Flores,Stefania Proietti,Stefano Bonassi,Solange Costa,João Paulo Teixeira,Juan Fernández‐Tajes,Eduardo Pásaro,Blanca Laffón,Vanessa Valdiglesias
出处
期刊:GeroScience
[Springer Nature]
日期:2020-08-15
卷期号:42 (6): 1451-1473
被引量:70
标识
DOI:10.1007/s11357-020-00247-4
摘要
Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. “Inflammaging”, an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146–56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.
科研通智能强力驱动
Strongly Powered by AbleSci AI