表面等离子共振
检出限
材料科学
光纤
生物传感器
志贺氏菌
光纤传感器
等离子体子
光电子学
纳米颗粒
纳米技术
光学
化学
物理
色谱法
生物化学
大肠杆菌
基因
作者
Santosh Kumar,Zhu Guo,Ragini Singh,Qinglin Wang,Bingyuan Zhang,Shuang Cheng,Fengzhen Liu,Carlos Marques,Brajesh Kumar Kaushik,Rajan Jha
标识
DOI:10.1109/jlt.2020.3036610
摘要
Present study demonstrates the fiber-optic localized surface plasmon resonance (LSPR) based sensitive biosensor for detection of Shigella bacterial species. The proposed sensor is comprised of multi-core fiber (MCF) having seven cores arranged in a hexagonal shape and spliced with single-mode fiber (SMF) for efficient detection. An increase in evanescent waves (EWs) and coupling of modes between MCF cores was achieved by etching process in a controlled manner. The etching process also increases the refractive index sensitivity (RIS) of the proposed sensor. Further, coating with nanomaterials like gold nanoparticles (AuNPs) and molybdenum disulfide (MoS 2 ) helps in the excitation of localized plasmons. Here, Shigella specific oligonucleotide probes are used as a recognition element. The results demonstrate that the proposed sensor can successfully and efficiently detect the Shigella bacterial species with high sensitivity. Shigella in the range of 10 - 100 CFU/mL (colony-forming unit/mL) can cause serious intestinal infection and therefore, its detection in this range is critical. The proposed sensor demonstrates a linearity range from 1 to 10 9 CFU/mL with a detection time of 5 min and a limit of detection (LoD) of 1.56 CFU/mL. The proposed sensing methodology can be a potential alternative to the commercially existing ones in the near future.
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