材料科学
透明质酸
聚吡咯
自愈水凝胶
生物医学工程
胶粘剂
导电聚合物
壳聚糖
聚合物
化学工程
纳米技术
高分子化学
复合材料
医学
聚合
工程类
解剖
图层(电子)
作者
Tengling Wu,Chunyan Cui,Yuting Huang,Yang Liu,Chuanchuan Fan,Xiaoxu Han,Yang Yang,Ziyang Xu,Бо Лю,Guanwei Fan,Wenguang Liu
标识
DOI:10.1021/acsami.9b17907
摘要
Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels and epicardial biomaterial patches, have been pursued to treat myocardial infarction. However, only limited therapeutic efficacy is achieved with a single means. Here, a combined therapy approach is proposed, that is, the coadministration of a conductive hydrogel patch and injectable hydrogel to the infarcted myocardium. The self-adhesive conductive hydrogel patch is fabricated based on Fe3+-induced ionic coordination between dopamine–gelatin (GelDA) conjugates and dopamine-functionalized polypyrrole (DA–PPy), which form a homogeneous network. The injectable and cleavable hydrogel is formed in situ via a Schiff base reaction between oxidized sodium hyaluronic acid (HA-CHO) and hydrazided hyaluronic acid (HHA). Compared with a single-mode system, injecting the HA-CHO/HHA hydrogel intramyocardially followed by painting a conductive GelDA/DA–PPy hydrogel patch on the heart surface results in a more pronounced improvement of the cardiac function in terms of echocardiographical, histological, and angiogenic outcomes.
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