Nanozyme-catalyzed oxygen release from calcium peroxide nanoparticles for accelerated hypoxia relief and image-guided super-efficient photodynamic therapy

The accelerated O₂ release from CaO₂ catalyzed by MnO₂ nanozyme leads to a rapid and efficient hypoxia relief, an increased yield of ¹O₂, a down-regulated HIF-1α and VEGF, and eventually a super-efficient PDT.