纳米棒
红外线的
视网膜
瞬时受体电位通道
感光度
光电子学
视网膜
材料科学
神经节细胞层
光谱灵敏度
视网膜变性
波长
光学
化学
生物物理学
神经科学
纳米技术
物理
生物
受体
生物化学
作者
Dasha Nelidova,Rei Morikawa,Cameron S. Cowan,Zoltán Raics,David Goldblum,Hendrik P. N. Scholl,Tamás Szikra,Arnold Szabó,Dániel Hillier,Botond Roska
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-06-04
卷期号:368 (6495): 1108-1113
被引量:94
标识
DOI:10.1126/science.aaz5887
摘要
Enabling near-infrared light sensitivity in a blind human retina may supplement or restore visual function in patients with regional retinal degeneration. We induced near-infrared light sensitivity using gold nanorods bound to temperature-sensitive engineered transient receptor potential (TRP) channels. We expressed mammalian or snake TRP channels in light-insensitive retinal cones in a mouse model of retinal degeneration. Near-infrared stimulation increased activity in cones, ganglion cell layer neurons, and cortical neurons, and enabled mice to perform a learned light-driven behavior. We tuned responses to different wavelengths, by using nanorods of different lengths, and to different radiant powers, by using engineered channels with different temperature thresholds. We targeted TRP channels to human retinas, which allowed the postmortem activation of different cell types by near-infrared light.
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