Enantioselective NiH‐Catalyzed Reductive Hydrofunctionalization of Alkenes

Enantioselective NiH-catalyzed reductive hydrofunctionalization of olefins has attracted much attention in recent years. Using simple chiral ligands, a wide array of functionalized olefins and electrophiles can undergo diverse transformations to afford hydrofunctionalized products, regio- and enantioselectively. These processes avoid the prior preparation of organometallic reagents, and can construct a stereogenic center at a carbon originating either from the olefin or from the electrophile. This review discusses the background, major progress and mechanistic investigations in this reaction. This article is protected by copyright. All rights reserved.