PA700 Regulatory Module

Ubiquitinated proteins are degraded by a 26S AT P-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules.T he multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related AT Pases and approximately fifteen non-AT Pase polypeptides.Each of the AT Pases, PSMC1-6, contains an AAA (AT Pases associated with diverse cellular activities) domain.A protein complex containing p42 and p50 enhances PA700 activation of the proteasome.