Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study

医学 内科学 肝细胞癌 癌症 胃肠病学 优势比 乙型肝炎病毒 孟德尔随机化 乙型肝炎 肿瘤科 免疫学 病毒 生物 基因型 生物化学 基因 遗传变异
作者
Abram Bunya Kamiza,Segun Fatumo,Mwiza Gideon Singini,Chih‐Ching Yeh,Tinashe Chikowore
出处
期刊:EBioMedicine [Elsevier]
卷期号:79: 104003-104003 被引量:6
标识
DOI:10.1016/j.ebiom.2022.104003
摘要

BackgroundEvidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined.MethodsWe performed two-sample Mendelian randomization (MR) to investigate whether chronic HBV infection is causally associated with extrahepatic cancers. We identified four independent genetic variants strongly associated (P-value < 5 × 10−8) with the exposure, chronic HBV infection in 1371 cases and 2938 controls of East Asian ancestry in Korea, which were used as instrumental variables. Genome-wide association summary level data for outcome variables, that included cancer of the biliary tract, cervix, colorectum, endometrium, esophagus, gastric, hepatocellular carcinoma, lung, ovary and pancreas were obtained from Biobank Japan.FindingsUsing the multivariable inverse variance weighted method, we found genetic liability to chronic HBV infection causally associated with extrahepatic cancers including cervical cancer (odds ratio [OR] = 1.57, 95% confidence interval [CI] = 1.29–1.91, P-value = 0.0001) and gastric cancer (OR = 1.12, 95% CI = 1.05–1.19, P-value = 0.0001). Moreover, chronic HBV infection (OR = 1.20, 95% CI = 1.07–1.34, P-value = 0.0021) was causally associated with hepatocellular carcinoma, supporting a well-established association between chronic HBV infection and hepatocellular carcinoma.InterpretationOur MR analysis revealed that chronic HBV infection is causally associated with extrahepatic cancers including cervical and gastric cancers.FundingNone.
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