Health effects of exposure to indoor volatile organic compounds from 1980 to 2017: A systematic review and meta‐analysis

荟萃分析 医学 哮喘 相对风险 观察研究 环境卫生 置信区间 化学 内科学 有机化学
作者
Ningrui Liu,Zhongming Bu,Wei Liu,Haidong Kan,Zhuohui Zhao,Furong Deng,Chen Huang,Bin Zhao,Xiangang Zeng,Yuexia Sun,Hua Qian,Jinhan Mo,Chanjuan Sun,Jianguo Guo,Xiaohong Zheng,Louise B. Weschler,Yinping Zhang
出处
期刊:Indoor Air [Wiley]
卷期号:32 (5) 被引量:67
标识
DOI:10.1111/ina.13038
摘要

Exposure to volatile organic compounds (VOCs) indoors is thought to be associated with several adverse health effects. However, we still lack concentration–response (C-R) relationships between VOC levels in civil buildings and various health outcomes. For this paper, we conducted a systematic review and meta-analysis of observational studies to summarize related associations and C-R relationships. Four databases were searched to collect all relevant studies published between January 1980 and December 2017. A total of 39 studies were identified in the systematic review, and 32 of these were included in the meta-analysis. We found that the pooled relative risk (RR) for leukemia was 1.03 (95% CI: 1.01–1.05) per 1 μg/m3 increase of benzene and 1.25 (95%CI: 1.14–1.37) per 0.1 μg/m3 increase of butadiene. The pooled RRs for asthma were 1.08 (95% CI: 1.02–1.14), 1.02 (95% CI: 1.00–1.04), and 1.04 (95% CI: 1.02–1.06) per 1 μg/m3 increase of benzene, toluene, and p-dichlorobenzene, respectively. The pooled RR for low birth weight was 1.12 (95% CI: 1.05–1.19) per 1 μg/m3 increase of benzene. Our findings provide robust evidence for associations between benzene and leukemia, asthma, and low birth weight, as well as for health effects of some other VOCs.
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