A novel synthesis method and properties of calcium-deficient hydroxyapatite/α-TCP biphasic calcium phosphate

Biphasic calcium phosphate (BCP) is an important research field based on calcium phosphate biomaterials. In this paper, a new synthesis method of CDHA/α-TCP BCP was studied. By controlling the addition amount of citric acid, the relative contents of CDHA and α-TCP in the BCP were controlled. BCP bone cement was prepared with different proportions of BCP as raw materials. The BCP bone cement was characterized by XRD and SEM, and evaluated by measuring setting time, compressive strength, SBF immersion, and colorimetric CCK-8 assay. The results showed that the increase of CDHA content can lead to the reduction of the setting time of bone cement and delay the degradation rate of BCP bone cement.