伤口愈合
伤口闭合
刺激
背景(考古学)
生物医学工程
医学
材料科学
外科
生物
内科学
古生物学
作者
Guang Yao,Xiaoyi Mo,Chenhui Yin,Wenhao Lou,Qian Wang,Sirong Huang,Linna Mao,Sihong Chen,Kangning Zhao,Taisong Pan,Lin Huang,Yuan Lin
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-01-26
卷期号:8 (4)
被引量:62
标识
DOI:10.1126/sciadv.abl8379
摘要
Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature-activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device.
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