促红细胞生成素肝细胞(Eph)受体
以法林
EPH受体A2
受体酪氨酸激酶
受体蛋白酪氨酸激酶
血管生成
细胞生物学
受体
生物
信号转导
癌变
癌症研究
癌症
遗传学
作者
Julio Castaño,Verónica Dávalos,Simó Schwartz,Diego Arango
出处
期刊:PubMed
日期:2008-08-01
卷期号:23 (8): 1011-23
被引量:12
摘要
EPH receptors and their ephrin ligands constitute the largest sub-family of receptor tyrosine kinases (RTKs) and are components of cell signaling pathways involved in animal development. The ability of the EPH/ephrin guidance system to position cells and modulate cell morphology underlies their various roles in development. In addition, EPH signaling plays an important role in oncogenic processes observed in several organs. These receptors are involved in a wide range of processes directly related with tumorigenesis and metastasis, including cell attachment and shape, migration, and angiogenesis. Accordingly, deregulation of EPH expression and signaling activity could be crucial for the tumorigenic process. This review focuses on EPH receptors' roles in oncogenic transformation and tumor progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI