材料科学
白藜芦醇
相容性(地球化学)
药品
药物输送
溶解度
差示扫描量热法
色谱法
赋形剂
硬脂酸镁
溶解
化学
作者
Michele Schlich,Francesco Lai,Anna Maria Fadda,Chiara Sinico,Elena Pini
标识
DOI:10.1166/jnn.2021.19056
摘要
Proniosomal drug delivery system is one of the advancements in nanotechnology. Similarly to traditional dosage forms, chemical and physical compatibility of proniosomes components with the active ingredient(s) is a key step in the preformulation process of such systems. In this work, the compatibility of resveratrol with selected excipients in the development of proniosomal formulation was investigated by thermal and spectroscopic techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric study, attenuated total reflectance Fourier transform infrared spectroscopy study and powder X-ray diffraction were adopted. The results showed that the excipients used in the formulation were compatible with resveratrol.
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