摘要
NanomedicineVol. 16, No. 13 EditorialNanomedicine-induced pyroptosis for cancer therapySadia Nadeem‡, Zheng Chen‡, Min Wei, Fangyuan Li & Daishun LingSadia Nadeem‡Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China, Zheng Chen‡Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China, Min WeiInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China, Fangyuan Li**Author for correspondence: E-mail Address: lfy@zju.edu.cnInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, ChinaHangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China & Daishun Ling *Author for correspondence: E-mail Address: dsling@sjtu.edu.cnhttps://orcid.org/0000-0002-9977-0237Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, ChinaSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaHangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, ChinaKey Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310058, ChinaPublished Online:4 May 2021https://doi.org/10.2217/nnm-2021-0063AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: cancer therapygasdermininflammasomesnanomedicinespyroptosisReferences1. Ganesan K, Xu B. Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. Ann. NY Acad. Sci. 1401(1), 102–113 (2017).Crossref, Medline, CAS, Google Scholar2. Wallach D, Kang TB, Dillon CP, Green DR. Programmed necrosis in inflammation: toward identification of the effector molecules. Science 352(6281), aaf2154 (2016).Crossref, Medline, Google Scholar3. Tang R, Xu J, Zhang B et al. Ferroptosis, necroptosis, and pyroptosis in anticancer immunity. J. Hematol. Oncol. 13(1), 110 (2020).Crossref, Medline, Google Scholar4. Elion DL, Jacobson ME, Hicks DJ et al. Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers. Cancer Res. 78(21), 6183–6195 (2018).Crossref, Medline, CAS, Google Scholar5. Wang Q, Wang Y, Ding J et al. A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature 579(7799), 421–426 (2020).Crossref, Medline, CAS, Google Scholar6. Reisetter AC, Stebounova LV, Baltrusaitis J et al. Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles. J. Biol. Chem. 286(24), 21844–21852 (2011).Crossref, Medline, CAS, Google Scholar7. Zhang X, Luan J et al. Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis. Nanoscale 10(19), 9141–9152 (2018).Crossref, Medline, CAS, Google Scholar8. Zychlinsky A, Prevost MC, Sansonetti PJ. Shigella flexneri induces apoptosis in infected macrophages. Nature 358(6382), 167–169 (1992).Crossref, Medline, CAS, Google Scholar9. Galluzzi L, Vitale I, Aaronson SA et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25(3), 486–541 (2018).Crossref, Medline, Google Scholar10. Shi J, Zhao Y, Wang K et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526(7575), 660–665 (2015).Crossref, Medline, CAS, Google Scholar11. Kayagaki N, Lee BL et al. IRF2 transcriptionally induces GSDMD expression for pyroptosis. Sci. Signal. 12(582), (2019).Crossref, Medline, Google Scholar12. Ramos-Junior ES, Morandini AC. Gasdermin: a new player to the inflammasome game. Biomed. J. 40(6), 313–316 (2017).Crossref, Medline, Google Scholar13. Ding J, Wang K, Liu W et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535(7610), 111–116 (2016).Crossref, Medline, CAS, Google Scholar14. Liu X, Zhang Z, Ruan J, Pan Y et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535(7610), 153–158 (2016).Crossref, Medline, CAS, Google Scholar15. Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21(7), 677–687 (2015).Crossref, Medline, Google Scholar16. Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem. Sci. 42(4), 245–254 (2017).Crossref, Medline, CAS, Google Scholar17. Wang S, Yuan YH, Chen NH, Wang HB. The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease. Int. Immunopharmacol. 67, 458–464 (2019).Crossref, Medline, CAS, Google Scholar18. Brojatsch J, Lima H Jr, Palliser D, Jacobson LS et al. Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents. Cell Cycle 14(7), 964–972 (2015).Crossref, Medline, CAS, Google Scholar19. Moossavi M, Parsamanesh N, Bahrami A, Atkin SL, Sahebkar A. Role of the NLRP3 inflammasome in cancer. Mol. Cancer 17(1), 158 (2018).Crossref, Medline, CAS, Google Scholar20. Wei Q, Mu K, Li T et al. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression. Lab Invest. 94(1), 52–62 (2014).Crossref, Medline, CAS, Google Scholar21. Zhou B, Zhang JY, Liu XS et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 28(12), 1171–1185 (2018).Crossref, Medline, CAS, Google Scholar22. Wang Y, Gao W, Shi X et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547(7661), 99–103 (2017).Crossref, Medline, CAS, Google Scholar23. Johnson DC, Taabazuing CY, Okondo MC et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat. Med. 24(8), 1151–1156 (2018).Crossref, Medline, CAS, Google Scholar24. Bazak R, Houri M, Achy SE, Hussein W, Refaat T. Passive targeting of nanoparticles to cancer: a comprehensive review of the literature. Mol. Clin. Oncol. 2(6), 904–908 (2014).Crossref, Medline, Google Scholar25. Ploetz E, Zimpel A, Cauda V et al. Metal-organic framework nanoparticles induce pyroptosis in cells controlled by the extracellular pH. Adv. Mater. 32(19), e1907267 (2020).Crossref, Medline, CAS, Google Scholar26. Nadeem S, Yang C, Du Y et al. A virus-spike tumor-activatable pyroptotic agent. Small 16(31), 2002537 (2021).Google Scholar27. Saeki N, Usui T, Aoyagi K et al. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer 48(3), 261–271 (2009).Crossref, Medline, CAS, Google Scholar28. Kim MS, Chang X, Yamashita K et al. Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma. Oncogene 27(25), 3624–3634 (2008).Crossref, Medline, CAS, Google Scholar29. Kim MS, Lebron C, Nagpal JK et al. Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem. Biophys. Res. Commun. 370(1), 38–43 (2008).Crossref, Medline, CAS, Google Scholar30. Aglietti RA, Dueber EC. Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions. Trends Immunol. 38(4), 261–271 (2017).Crossref, Medline, CAS, Google Scholar31. Fan JX, Deng RH, Wang H et al. Epigenetics-based tumor cells pyroptosis for enhancing the immunological effect of chemotherapeutic nanocarriers. Nano Lett. 19(11), 8049–8058 (2019).Crossref, Medline, CAS, Google Scholar32. Zhao P, Wang M, Chen M et al. Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy. Biomaterials 254, 120142 (2020).Crossref, Medline, CAS, Google Scholar33. Zhao H, Song Q, Zheng C et al. Implantable bioresponsive nanoarray enhances postsurgical immunotherapy by activating pyroptosis and remodeling tumor microenvironment. Adv. Funct. Mater. 30(51), 2005747 (2020).Crossref, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 16, No. 13 Follow us on social media for the latest updates Metrics Downloaded 402 times History Received 17 February 2021 Accepted 2 March 2021 Published online 4 May 2021 Published in print June 2021 Information© 2021 Future Medicine LtdKeywordscancer therapygasdermininflammasomesnanomedicinespyroptosisAuthor contributionsS Nadeem, Z Chen and M Wei reviewed literature and wrote text together. F Li and D Ling supervised S Nadeem, Z Chen and M Wei and revised the text. Each co-author listed participated sufficiently in the work to take responsibility for the content.Financial & competing interests disclosureThis work is supported by the National Key Research and Development Program of China (2016YFA0203600), the National Natural Science Foundation of China (31822019, 32071374, 91859116 and 81761148029), One Belt and One Road International Cooperation Project from Key Research and Development Program of Zhejiang Province (2019C04024), the Zhejiang Provincial Natural Science Foundation (LGF19C100002), the Fundamental Research Funds for the Central Universities (2020FZZX001-05). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download