医学
脊髓损伤
随机对照试验
痉挛
物理疗法
功能独立性测度
四肢瘫痪
神经假体
自主反射障碍
物理医学与康复
生活质量(医疗保健)
截瘫
脊髓
康复
外科
护理部
精神科
作者
Helge Kasch,A. A. W. van Geloven,Anette Bach Jønsson,Kaare Severinsen,Marc Possover,Søren Bruno Elmgreen,Axel Forman
出处
期刊:Spinal Cord
[Springer Nature]
日期:2021-08-24
卷期号:60 (3): 251-255
被引量:2
标识
DOI:10.1038/s41393-021-00693-7
摘要
1-year prospective RCT.Examine the effect of implantable pulse generator and low-frequency stimulation of the pelvic nerves using laparoscopic implantation of neuroprosthesis (LION) compared with neuromuscular electrical stimulation (NMES) in SCI.Inclusion criteria: traumatic spinal cord injury (SCI), age 18-55 years, neurological level-of-injury Th4-L1, time-since-injury >1 year, and AIS-grades A-B. Participants were randomized to (A) LION procedure or (B) control group receiving NMES.Walking Index for Spinal Cord Injury (WISCI-II), which is a SCI specific outcome measure assessing ability to ambulate.Spinal Cord Independence Measure III (SCIM III), Patient Global Impression of Change (PGIC), Penn Spasm Frequency Scale (PSFS), severity of spasticity measured by Numeric Rating Scale (NRS-11); International Spinal Cord Injury data sets-Quality of Life Basic Data Set (QoLBDS), and Brief Pain Inventory (BPI).Seventeen SCI individuals, AIS grade A, neurological level ranging from Th4-L1, were randomized to the study. One individual was excluded prior to intervention. Eight participants (7 males) with a mean age (SD) of 35.5 (12.4) years were allocated to the LION procedure, 8 participants (7 males) with age of 38.8 (15.1) years were allocated to NMES. Significantly, 5 LION group participants gained 1 point on the WISCI II scale, (p < 0.013; Fisher´s exact test). WISCI II scale score did not change in controls. No significant changes were observed in the secondary outcome measures.The LION procedure is a promising new treatment for individuals with SCI with significant one-year improvement in walking ability.
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