偷看
磺酸盐
材料科学
抗菌活性
粘附
骨科手术
方位(导航)
体外
大肠杆菌
金黄色葡萄球菌
牙科
生物医学工程
医学
化学
外科
复合材料
生物化学
聚合物
细菌
生物
冶金
钠
地理
基因
地图学
遗传学
作者
Lvhua Liu,Shouxin Zhang,Lei Yuan,Ying Liu,Yanyan Zheng
标识
DOI:10.1016/j.matlet.2021.130774
摘要
Polyetheretherketone (PEEK) has a similar elastic modulus to that of human bone and is considered a promising alternative for biomedical metallic implants. However, the poor antibacterial, anti-inflammatory, and osteogenic activity of bioinert PEEK impedes its clinical use for orthopedic and dental implants. Furthermore, using a single functional strategy to achieve all three biological functions simultaneously is challenging. Previous studies have demonstrated that sulfonate-bearing surfaces have antibacterial activity as well as decreased secretion of pro-inflammatory cytokine TNF-α. Therefore, in this study, sulfonate groups were introduced onto the PEEK surface by a one-step ultraviolet-initiated graft polymerization method. In vitro studies revealed enhanced adhesion, spreading, proliferation, and osteo-differentiation of MC3T3-E1 osteoblasts. Furthermore, the sulfonate-bearing PEEK had anti-inflammatory properties, and antibacterial activity to Escherichia coli and Staphylococcus aureus. Collectively, our findings indicate that PEEK implants bearing sulfonate groups with ameliorative antibacterial, anti-inflammatory, and osteogenic activity have potential clinical applications as orthopedic and dental implants.
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