丝素
丝绸
明胶
甲基丙烯酸酯
高分子科学
沉积作用
高分子化学
粘度
材料科学
化学工程
化学
作者
Kyunga Na,Sung-Chul Shin,Hyunji Lee,Donghyeok Shin,Jihye Baek,Hojung Kwak,Minsung Park,Jeon-Soo Shin,Jinho Hyun
标识
DOI:10.1016/j.jiec.2017.12.032
摘要
Abstract To improve the cell suspension of the gelatin-methacrylate(GelMA) bioink, the viscosity of the ink solution was controlled by biocompatible silk fibroin(SF) particles. The viscosity of the GelMA solution increased about 1.4 × 102 folds by the addition of 1 w/v% SF particles. The increase of solution viscosity reduced the displacement of cells and retarded the cell sedimentation significantly. SF-GelMA bioink containing 1 w/v% SF was non-cytotoxic and used for the 3D bioprinting by directly projecting a feature onto the bioink. The cells encapsulated in the structures showed a high level of metabolic activity and demonstrated that SF-GelMA was a biocompatible material.
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