自噬
神经退行性变
细胞生物学
背景(考古学)
机制(生物学)
生物
程序性细胞死亡
神经科学
细胞凋亡
遗传学
医学
认识论
哲学
病理
古生物学
疾病
作者
Ivan Đikić,Zvulun Elazar
标识
DOI:10.1038/s41580-018-0003-4
摘要
Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the event of energy or nutrient shortage and responds to various cytotoxic insults. Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimuli that cells experience, thereby conferring adaptation to the ever-changing environment. It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
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