医学
接收机工作特性
预测值
曲线下面积
肺癌
呼出的空气
内科学
曲线下面积
胃肠病学
生物
毒理
药代动力学
作者
Ángela Guirao Montes,Laureano Molins López-Rodó,Ingrid Ramón Rodríguez,Gemma Sunyer Dequigiovanni,Núria Segarra,Ramón María Marrades Sicart,Jorge Hernández,Juan José Fibla Alfara,Álvaro Agustí García-Navarro
摘要
Early lung cancer (LC) diagnosis is key to improve prognosis. We explored here the diagnostic performance of a trained dog to discriminate exhaled gas samples obtained from patients with and patients without LC and healthy controls.After appropriate training, we exposed the dog (a 3-year-old cross-breed between a Labrador Retriever and a Pitbull) to 390 samples of exhaled gas collected from 113 individuals (85 patients with LC and 28 controls, which included 11 patients without LC and 17 healthy individuals) for a total of 785 times.The trained dog recognized LC in exhaled gas with a sensitivity of 0.95, a specificity of 0.98, a positive predictive value of 0.95 and a negative predictive value of 0.98. The area under the curve of the receiver-operating characteristics curve was 0.971.This study shows that a well-trained dog can detect the presence of LC in exhaled gas samples with an extremely high accuracy.
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