Voltammetric Determination of Salicylic Acid by Molecularly Imprinted Film Modified Electrodes

Abstract A highly selective and sensitive voltammetric sensor for salicylic acid was introduced. The sensitive layer was prepared by electropolymerization of pyrrole on a glassy carbon electrode in the presence of salicylic acid as a template. The template could be removed effectively by a two-step method. The first step was fixed potential peroxide and the second step was alkali solution washing. A wide dynamic linear range of 5.0 × 10−9 to 1.0 × 10−3 mol · L−1 was obtained. The imprinted sensor could be easily fabricated and showed a stable and reproducible response without any influence of interferents commonly existing in drug combination samples. Keywords: DeterminationMolecularly imprinted polymerSalicylic acidVoltammetric sensor Acknowledgments This work is supported by the National Natural Science Foundation of China (Nos. 20965007, 20927004, 21065010). We also thank Key Laboratory of Eco-Environment-Related Polymer Materials (Northwest Normal University), Ministry of Education, for financial support. Notes Represents the average of five times determination.