亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

A Randomized, Prospective, Comparison Study of a Mixture of Acacia Fiber, Psyllium Fiber, and Fructose vs Polyethylene Glycol 3350 with Electrolytes for the Treatment of Chronic Functional Constipation in Childhood

医学 PEG比率 便秘 泻药 胃肠病学 前瞻性队列研究 不利影响 功能性便秘 内科学 随机对照试验 木虱 排便 外科 膳食纤维 化学 经济 食品科学 财务
作者
Paolo Quitadamo,Paola Coccorullo,Eleonora Giannetti,Claudio Romano,Andrea Chiaro,Angelo Campanozzi,Emanuela Poli,Salvatore Cucchiara,Giovanni Di Nardo,Annamaria Staiano
出处
期刊:The Journal of Pediatrics [Elsevier BV]
卷期号:161 (4): 710-715.e1 被引量:44
标识
DOI:10.1016/j.jpeds.2012.04.043
摘要

Objectives To compare the effectiveness of a mixture of acacia fiber, psyllium fiber, and fructose (AFPFF) with polyethylene glycol 3350 combined with electrolytes (PEG+E) in the treatment of children with chronic functional constipation (CFC); and to evaluate the safety and effectiveness of AFPFF in the treatment of children with CFC. Study design This was a randomized, open label, prospective, controlled, parallel-group study involving 100 children (M/F: 38/62; mean age ± SD: 6.5 ± 2.7 years) who were diagnosed with CFC according to the Rome III Criteria. Children were randomly divided into 2 groups: 50 children received AFPFF (16.8 g daily) and 50 children received PEG+E (0.5 g/kg daily) for 8 weeks. Primary outcome measures were frequency of bowel movements, stool consistency, fecal incontinence, and improvement of other associated gastrointestinal symptoms. Safety was assessed with evaluation of clinical adverse effects and growth measurements. Results Compliance rates were 72% for AFPFF and 96% for PEG+E. A significant improvement of constipation was seen in both groups. After 8 weeks, 77.8% of children treated with AFPFF and 83% of children treated with PEG+E had improved (P = .788). Neither PEG+E nor AFPFF caused any clinically significant side effects during the entire course of the study period. Conclusions In this randomized study, we did not find any significant difference between the efficacy of AFPFF and PEG+E in the treatment of children with CFC. Both medications were proved to be safe for CFC treatment, but PEG+E was better accepted by children. To compare the effectiveness of a mixture of acacia fiber, psyllium fiber, and fructose (AFPFF) with polyethylene glycol 3350 combined with electrolytes (PEG+E) in the treatment of children with chronic functional constipation (CFC); and to evaluate the safety and effectiveness of AFPFF in the treatment of children with CFC. This was a randomized, open label, prospective, controlled, parallel-group study involving 100 children (M/F: 38/62; mean age ± SD: 6.5 ± 2.7 years) who were diagnosed with CFC according to the Rome III Criteria. Children were randomly divided into 2 groups: 50 children received AFPFF (16.8 g daily) and 50 children received PEG+E (0.5 g/kg daily) for 8 weeks. Primary outcome measures were frequency of bowel movements, stool consistency, fecal incontinence, and improvement of other associated gastrointestinal symptoms. Safety was assessed with evaluation of clinical adverse effects and growth measurements. Compliance rates were 72% for AFPFF and 96% for PEG+E. A significant improvement of constipation was seen in both groups. After 8 weeks, 77.8% of children treated with AFPFF and 83% of children treated with PEG+E had improved (P = .788). Neither PEG+E nor AFPFF caused any clinically significant side effects during the entire course of the study period. In this randomized study, we did not find any significant difference between the efficacy of AFPFF and PEG+E in the treatment of children with CFC. Both medications were proved to be safe for CFC treatment, but PEG+E was better accepted by children.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
sjyu1985完成签到 ,获得积分10
5秒前
闻巷雨完成签到 ,获得积分10
11秒前
pegasus0802完成签到 ,获得积分10
51秒前
5823364完成签到,获得积分10
1分钟前
automan完成签到,获得积分10
1分钟前
天亮polar完成签到,获得积分10
1分钟前
1分钟前
1分钟前
2分钟前
朴实云应发布了新的文献求助10
2分钟前
林子青完成签到,获得积分10
2分钟前
核桃发布了新的文献求助30
2分钟前
李健应助reerwt采纳,获得10
3分钟前
3分钟前
ICSSCI发布了新的文献求助10
3分钟前
3分钟前
刘宇童给刘宇童的求助进行了留言
3分钟前
reerwt发布了新的文献求助10
3分钟前
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
ICSSCI完成签到,获得积分10
3分钟前
4分钟前
董可以发布了新的文献求助10
4分钟前
风华正茂完成签到,获得积分10
4分钟前
4分钟前
4分钟前
jimmy_bytheway完成签到,获得积分0
4分钟前
桃桃发布了新的文献求助10
4分钟前
可爱的函函应助桃桃采纳,获得10
5分钟前
5分钟前
5分钟前
5分钟前
5分钟前
NexusExplorer应助科研通管家采纳,获得10
5分钟前
所所应助爱笑的毛衣采纳,获得10
5分钟前
5分钟前
6分钟前
duan完成签到 ,获得积分10
6分钟前
holder完成签到,获得积分10
6分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256369
捐赠科研通 3270998
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228