Uveitis is associated with hypertension and atherosclerosis in patients with ankylosing spondylitis: A cross-sectional study

医学 强直性脊柱炎 葡萄膜炎 内科学 巴斯菲 优势比 脊柱炎 疾病 家族史 横断面研究 逻辑回归 巴斯代人 眼科 病理 银屑病性关节炎
作者
Inger Jorid Berg,Anne Grete Semb,Désirée van der Heijde,Tore K Kvien,Jonny Hisdal,Inge Christoffer Olsen,Hanne Dagfinrud,Sella Aarrestad Provan
出处
期刊:Seminars in Arthritis and Rheumatism [Elsevier BV]
卷期号:44 (3): 309-313 被引量:21
标识
DOI:10.1016/j.semarthrit.2014.05.017
摘要

Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS), but the literature describing AS patients with a history of uveitis is limited. The objective was to examine if a history of uveitis in patients with AS is associated with increased disease activity and functional impairment and to investigate whether uveitis is associated with an increased frequency of cardiovascular comorbidities, defined here as hypertension and atherosclerosis.Data were recorded cross-sectionally through patient interviews, blood samples, clinical examination, and questionnaires. Carotid plaques were identified by ultrasonography. AS disease activity and function were compared across categories of uveitis using ANCOVA analyses. Associations between uveitis and hypertension and atherosclerosis [atherosclerotic cardiovascular disease (CVD) and/or carotid plaque] were analyzed in multivariate logistic regression models.Of 159 patients with AS (61.6% male, mean age 50.5 years), 84 (52.8%) had experienced one or more episodes of uveitis. AS disease activity was higher in patients with a history of uveitis, statistically significant for functional impairment [Bath AS Functional Index (BASFI)] [mean difference (95% CI)] lnBASFI = 0.2 (0.0-0.3), p = 0.05. Patients with uveitis had an increased odds ratio [OR (95% CI)] for hypertension [3.29 (1.29-8.41), p = 0.01] and atherosclerosis [2.57 (1.15-5.72), p = 0.02].AS patients with a history of uveitis had non-significantly higher disease activity and significantly higher functional impairment. A history of uveitis was associated with hypertension as well as atherosclerosis. These results may be important in identifying AS patients with elevated risk of CVD but should be confirmed in longitudinal cohorts.
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