色谱法
质谱法
化学
生物标志物发现
生物标志物
分辨率(逻辑)
代谢组学
液相色谱-质谱法
癌症
蛋白质组学
医学
内科学
生物化学
计算机科学
基因
人工智能
作者
Lin Lin,Quan Yu,Xiaomei Yan,Wei Hang,Jiaxin Zheng,Jinchun Xing,Benli Huang
出处
期刊:Analyst
[The Royal Society of Chemistry]
日期:2010-01-01
卷期号:135 (11): 2970-2970
被引量:141
摘要
Serum samples from kidney cancer patients and healthy controls were analyzed by both direct infusion mass spectrometry (DIMS) and liquid chromatography-mass spectrometry (LC-MS) with a high resolution ESI-Q-TOFMS. The classification and biomarker discovery capacities of the two methods were compared, and MS/MS experiments were carried out to identify potential biomarkers. DIMS had comparable classification and prediction capabilities to LC-MS but consumed only ∼5% of the analysis time. With regard to biomarker discovery, twenty-three variables were found as potential biomarkers by DIMS, and 48 variables were obtained by LC-MS. DIMS is recommended to be a fast diagnostic method for kidney cancer, while LC-MS is necessary when comprehensive screening of biomarkers is required.
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