DNA修复
DNA
基因
DNA损伤
生物
DNA修复蛋白XRCC4
雷达51
DNA聚合酶
紫外线
遗传学
计算生物学
DNA错配修复
化学
光化学
作者
Richard D. Wood,Michael Mitchell,John Sgouros,Tomas Lindahl
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2001-02-16
卷期号:291 (5507): 1284-1289
被引量:1439
标识
DOI:10.1126/science.1056154
摘要
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.
科研通智能强力驱动
Strongly Powered by AbleSci AI