Sertraline-Induced Hyperglycemia: Case Report

Empirical studies with humans suggest that selective serotonin reuptake inhibitors (SSRIs) may, through increases in serotonergic activity [1], increase insulin secretion [2], increase insulin sensitivity [3], and lower serum glucose levels [1]. Indeed, the potentially beneficial effects of SSRI treatment in diabetics are documented. However, we describe the case of a female, with diet-controlled, type 2 diabetes, whose glucose levels increased with exposure to sertraline.