亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Midlife vs Late-Life Depressive Symptoms and Risk of Dementia

痴呆 萧条(经济学) 危险系数 晚年抑郁症 医学 血管性痴呆 队列 比例危险模型 风险因素 精神科 神经学 队列研究 疾病 老年学 内科学 置信区间 认知 经济 宏观经济学
作者
Deborah E. Barnes,Kristine Yaffe,Amy L. Byers,Mark A. McCormick,Catherine Schaefer,Rachel A. Whitmer
出处
期刊:Archives of General Psychiatry [American Medical Association]
卷期号:69 (5): 493-493 被引量:390
标识
DOI:10.1001/archgenpsychiatry.2011.1481
摘要

Context

Depression and dementia are common in older adults and often co-occur, but it is unclear whether depression is an etiologic risk factor for dementia.

Objective

To clarify the timing and nature of the association between depression and dementia.

Design

We examined depressive symptoms assessed in midlife (1964-1973) and late life (1994-2000) and the risks of dementia, Alzheimer disease (AD), and vascular dementia (VaD) (2003-2009) in a retrospective cohort study. Depressive symptoms were categorized as none, midlife only, late life only, or both. Cox proportional hazards models (age as timescale) adjusted for demographics and medical comorbidities were used to examine depressive symptom category and risk of dementia, AD, or VaD.

Setting

Kaiser Permanente Medical Care Program of Northern California.

Participants

Thirteen thousand five hundred thirty-five long-term Kaiser Permanente members.

Main Outcome Measure

Any medical record diagnosis of dementia or neurology clinic diagnosis of AD or VaD.

Results

Subjects had a mean (SD) age of 81.1 (4.5) years in 2003, 57.9% were women, and 24.2% were nonwhite. Depressive symptoms were present in 14.1% of subjects in midlife only, 9.2% in late life only, and 4.2% in both. During 6 years of follow-up, 22.5% were diagnosed with dementia (5.5% with AD and 2.3% with VaD). The adjusted hazard of dementia was increased by approximately 20% for midlife depressive symptoms only (hazard ratio, 1.19 [95% CI, 1.07-1.32]), 70% for late-life symptoms only (1.72 [1.54-1.92]), and 80% for both (1.77 [1.52-2.06]). When we examined AD and VaD separately, subjects with late-life depressive symptoms only had a 2-fold increase in AD risk (hazard ratio, 2.06 [95% CI, 1.67-2.55]), whereas subjects with midlife and late-life symptoms had more than a 3-fold increase in VaD risk (3.51 [2.44-5.05]).

Conclusions

Depressive symptoms in midlife or in late life are associated with an increased risk of developing dementia. Depression that begins in late life may be part of the AD prodrome, while recurrent depression may be etiologically associated with increased risk of VaD.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
狐狸萌萌哒完成签到 ,获得积分10
7秒前
欢欢完成签到,获得积分10
10秒前
12秒前
12秒前
spark810应助科研通管家采纳,获得10
15秒前
顾矜应助科研通管家采纳,获得10
16秒前
spark810应助科研通管家采纳,获得10
16秒前
科研通AI2S应助科研通管家采纳,获得30
16秒前
吴炜华发布了新的文献求助10
18秒前
晴朗发布了新的文献求助10
20秒前
可爱的函函应助sping采纳,获得10
21秒前
25秒前
空岛与影发布了新的文献求助30
32秒前
吴炜华发布了新的文献求助10
35秒前
37秒前
充电宝应助22222采纳,获得30
43秒前
空岛与影完成签到,获得积分10
48秒前
52秒前
54秒前
22222发布了新的文献求助30
58秒前
菲莳完成签到 ,获得积分10
59秒前
热舞特完成签到,获得积分10
59秒前
吴炜华完成签到,获得积分10
1分钟前
1分钟前
街霸发布了新的文献求助10
1分钟前
凡yeah完成签到,获得积分10
1分钟前
凡yeah发布了新的文献求助10
1分钟前
1分钟前
棠真完成签到 ,获得积分10
1分钟前
1分钟前
2分钟前
2分钟前
2分钟前
Jolly发布了新的文献求助10
2分钟前
拼搏小丸子完成签到 ,获得积分10
2分钟前
2分钟前
慕青应助科研通管家采纳,获得10
2分钟前
pin发布了新的文献求助10
2分钟前
xzn发布了新的文献求助10
2分钟前
Jolly完成签到,获得积分20
2分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
New China Forges Ahead: Important Documents of the Third Session of the First National Committee of the Chinese People's Political Consultative Conference 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3056425
求助须知:如何正确求助?哪些是违规求助? 2713046
关于积分的说明 7434315
捐赠科研通 2357999
什么是DOI,文献DOI怎么找? 1249197
科研通“疑难数据库(出版商)”最低求助积分说明 606972
版权声明 596195