成纤维细胞生长因子受体4
FGF19型
成纤维细胞生长因子受体
成纤维细胞生长因子受体1
细胞生物学
细胞生长
生长因子
成纤维细胞
FGF1型
碳水化合物代谢
化学
成纤维细胞生长因子受体2
作者
Xunshan Ding,Jamie Boney-Montoya,Bryn M. Owen,Angie L. Bookout,Katie C. Coate,David J. Mangelsdorf,Steven A. Kliewer
标识
DOI:10.1016/j.cmet.2012.08.002
摘要
Fibroblast growth factor 21 (FGF21) is a fasting-induced hepatokine that has potent pharmacologic effects in mice, which include improving insulin sensitivity and blunting growth. The single-transmembrane protein βKlotho functions as a coreceptor for FGF21 in vitro. To determine if βKlotho is required for FGF21 action in vivo, we generated whole-body and adipose tissue-selective βKlotho-knockout mice. All of the effects of FGF21 on growth and metabolism were lost in whole-body βKlotho-knockout mice. Selective elimination of βKlotho in adipose tissue blocked the acute insulin-sensitizing effects of FGF21. Taken together, these data demonstrate that βKlotho is essential for FGF21 activity and that βKlotho in adipose tissue contributes to the beneficial metabolic actions of FGF21.
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