糖尿病前期
医学
吉
人口学
混淆
广义估计方程
队列
腹部肥胖
内科学
队列研究
人口
肥胖
糖尿病
代谢综合征
内分泌学
2型糖尿病
环境卫生
统计
数学
社会学
作者
Jia Liu,Zhanzheng Zhao,Yongmin Mu,Xiaoping Zou,Dechun Zou,Jingbo Zhang,Shuo Chen,Lixin Tao,Xiuhua Guo
标识
DOI:10.3390/ijerph15071560
摘要
This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort. A total of 8237 participants in the Beijing Health Management Cohort study were recruited and surveyed during 2008–2009, and followed up in 2011–2012 and 2014–2015 surveys. Generalized estimating equation (GEE) models were used to evaluate the association between SUA and prediabetes. Furthermore, subgroup analyses assessed the primary outcome according to status of abdominal obesity, age and status of hypertension. During six years of follow-up, we identified 1083 prediabetes events. The GEE analyses confirmed and clarified the association between SUA and prediabetes (RR = 1.362; 95% CI = 1.095–1.696; p = 0.006) after adjusting for other potential confounders, especially in females (RR = 2.109; 95% CI = 1.329–3.347; p = 0.002). In addition, this association was stronger in the subgroup of females aged ≥48 years old (RR = 2.384; 95% CI = 1.417–4.010; p = 0.001). The risk for prediabetes increased significantly with increasing SUA for females in the Chinese population. This association was strongly confirmed in older females aged ≥48 years old rather than in younger females, which may provide clues for pathogenic mechanisms of gender differences in the association between SUA and prediabetes.
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