Enantioseparation of Au20(PP3)4Cl4 Clusters with Intrinsically Chiral Cores

Abstract Au 20 (PP 3 ) 4 Cl 4 (PP 3 =tris(2‐(diphenylphosphino)ethyl) phosphine), abbreviated as Au 20 , is the only Au nanocluster with an intrinsically chiral core without a chiral environment (chiral ligands or Au‐thiolate staples), making it a unique object to understand chiral evolution and explore chiral applications. Unfortunately, the synthesized Au 20 is racemic, and its enantiomers have not yet been separated. Herein, we report a supramolecular assembly strategy with α‐cyclodextrin (α‐CD) to afford enantiopure Au 20 in bulk, and an enantiomer excess ( ee ) value of as‐separated Au 20 of 97 %. As a result of its high purity, the distinctive optical activity of Au 20 , which originates from electronic transitions confined in chiral cores, is fully explored. Theoretical studies reveals that the enantioseparation results from the preferential self‐assembly of α‐CD with organic ligands on the surface of right‐handed Au 20 .