CD38
单克隆抗体
多发性骨髓瘤
医学
抗原
造血
癌症研究
达拉图穆马
免疫学
免疫疗法
嵌合抗原受体
抗体
生物
干细胞
免疫系统
细胞生物学
川地34
作者
Francesca Bonello,Mattia D’Agostino,Maria Moscvin,Chiara Cerrato,Mario Boccadoro,Francesca Gay
标识
DOI:10.1080/14712598.2018.1544240
摘要
Introduction: Multiple myeloma (MM) is a currently incurable hematologic tumor with heterogeneous clinical behavior and prognosis. During the last years, survival improved due to a better understanding of MM biology and the development of novel drugs, although it still remains unsatisfactory in many cases: new drugs and treatment strategies are needed. CD38 is uniformly expressed at high levels on MM cells and, to a lesser extent, on the surface of normal hematopoietic and non-hematopoietic cells, making this molecule an interesting target for immunotherapeutic approaches.Areas covered: This review discusses the preclinical and clinical experience on different immunotherapeutic agents targeting CD38 in MM.Expert commentary: Monoclonal antibodies (mAbs) targeting CD38 are currently changing the treatment scenario in MM, allowing physicians to reach unprecedented results, especially when anti-CD38 mAbs are used in combination with consolidated MM treatments. Other immunotherapies targeting CD38 – such as conjugated anti-CD38 mAbs, bispecific antibodies stimulating T cells to eliminate CD38+ MM cells, and CD38-specific chimeric antigen receptor T cells – are interesting strategies, currently at earlier developmental stages.
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