Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin

海西定 慢性病贫血 医学 类风湿性关节炎 贫血 铁蛋白 血红蛋白 内科学 总铁结合能力 缺铁 红细胞生成 血清铁 免疫学 缺铁性贫血 胃肠病学 内分泌学
作者
Warqaa Khalaf,Haithem Ahmed Al-Rubaie,Sami Salman Shihab
出处
期刊:Hematology Reviews [PAGEPress Publications]
卷期号:11 (1): 7708-7708 被引量:15
标识
DOI:10.4081/hr.2019.7708
摘要

Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most important types of anemia in rheumatoid arthritis (RA). Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis. The aim is to investigate the role of circulating hepcidin and to uncover the frequency of IDA in RA. The study included 51 patients with RA. Complete blood counts, serum iron, total iron binding capacity, ferritin, and hepcidin- 25 were assessed. ACD was found in 37.3% of patients, IDA in 11.8%, and combined (ACD/IDA) in 17.6%. Serum hepcidin was higher in ACD than in control and the other groups (P ≤ 0.001). It was strongly and positively correlated with ferritin (P < 0.001), while hemoglobin, serum iron, and total iron binding capacity were negatively correlated with hepcidin (P = 0.016, 0.022 and <0.001, respectively). High serum hepcidin was significantly associated with ACD in RA. IDA alone or combined with ACD was encountered in about a third of patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Irissun完成签到,获得积分10
刚刚
道可道发布了新的文献求助10
1秒前
Jason举报困困卷毛猫求助涉嫌违规
1秒前
傲娇的寻凝完成签到,获得积分10
1秒前
科研小白完成签到,获得积分10
2秒前
2秒前
萧七七完成签到,获得积分10
3秒前
114555完成签到,获得积分10
3秒前
3秒前
4秒前
愉快棒棒糖完成签到,获得积分10
6秒前
fls221完成签到,获得积分10
6秒前
mirrovo完成签到 ,获得积分10
6秒前
6秒前
liuzhudi完成签到,获得积分10
6秒前
7秒前
yyy完成签到,获得积分10
8秒前
9秒前
小二郎应助半斤采纳,获得10
9秒前
所所应助道可道采纳,获得10
11秒前
安容天发布了新的文献求助10
12秒前
yyy发布了新的文献求助10
12秒前
欢喜的小天鹅完成签到 ,获得积分10
13秒前
75986686发布了新的文献求助10
13秒前
13秒前
hui关注了科研通微信公众号
14秒前
14秒前
myyy完成签到 ,获得积分10
14秒前
科目三应助fffan采纳,获得10
14秒前
sustwanli完成签到,获得积分20
15秒前
yyy完成签到,获得积分10
15秒前
大模型应助一米阳光采纳,获得10
15秒前
芝士芋泥完成签到 ,获得积分10
16秒前
mirror发布了新的文献求助10
16秒前
雪寒关注了科研通微信公众号
17秒前
18秒前
佳佳发布了新的文献求助30
19秒前
星辰大海应助安容天采纳,获得10
19秒前
YQF完成签到,获得积分10
19秒前
光亮映之发布了新的文献求助10
19秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546508
求助须知:如何正确求助?哪些是违规求助? 3123622
关于积分的说明 9356111
捐赠科研通 2822292
什么是DOI,文献DOI怎么找? 1551314
邀请新用户注册赠送积分活动 723303
科研通“疑难数据库(出版商)”最低求助积分说明 713699