酿酒酵母
芽殖酵母
计算生物学
酵母
DNA微阵列
模式生物
基因组
吞吐量
荧光显微镜
生物
计算机科学
遗传学
基因
基因表达
荧光
电信
物理
量子力学
无线
作者
Erin B. Styles,Helena Friesen,Charles Boone,Brenda Andrews
出处
期刊:CSH Protocols
[Cold Spring Harbor Laboratory]
日期:2016-04-01
卷期号:2016 (4): pdb.top087593-pdb.top087593
被引量:6
标识
DOI:10.1101/pdb.top087593
摘要
The budding yeast Saccharomyces cerevisiae has served as the pioneer model organism for virtually all genome-scale methods, including genome sequencing, DNA microarrays, gene deletion collections, and a variety of proteomic platforms. Yeast has also provided a test-bed for the development of systematic fluorescence-based imaging screens to enable the analysis of protein localization and abundance in vivo. Especially important has been the integration of high-throughput microscopy with automated image-processing methods, which has allowed researchers to overcome issues associated with manual image analysis and acquire unbiased, quantitative data. Here we provide an introduction to automated imaging in budding yeast.
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